Wednesday, August 20, 2008

Broccoli and reversal of diabetes complications

Nutrition-wise blog

With Mayo Clinic nutritionists Jennifer Nelson, M.S., R.D. and Katherine Zeratsky, R.D.

August 14, 2008 9:19 a.m.
Fascinating connection between broccoli and reversal of diabetes complications

I often glance at the online listings of journal articles that are available ahead of print. The following one from Diabetes, posted Aug. 4, 2008, went right by me:

"Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease."

Huh? It didn't catch my attention until the British Broadcasting Company (BBC) ran the story on Aug. 5 and translated it as: "Broccoli may undo diabetes damage."

This very interesting study looked at the phytochemical (plant compound) called sulforaphane. It seems to help produce enzymes in the body that protect blood vessels by reducing tissue damaging substances triggered by high blood sugar. Sulforaphane also seems to activate genes that regulate protective antioxidant and detoxifying enzymes.

Vascular disease is a major complication of diabetes. It leads to heart disease, stroke, damage to small vessels of the eye (blindness), kidney (failure that leads to dialysis), and circulation to extremities and possible amputation.

This isn't the first news about broccoli. In 2006, another broccoli compound was found to help boost genes that prevent damaged genetic information from being passed on to future generations of cells, thereby offering potential reduction in cancer risk.

In 2007, a nutrition study of men who had prostate cancer showed that a weekly serving of broccoli cut risk for the aggressive form of the disease by 45 percent.

In 2008, researchers found in an animal study that sulforaphane in broccoli protects the heart from damage when it is deprived of oxygen (such as what occurs when a coronary artery is blocked by a clot).

What makes the diabetes study so compelling is that it seems to actually identify mechanisms that the compound sulforaphane in broccoli trigger that may allow reversal of high blood sugar damage.

All of the studies point out the need for further research. They also point out that generous servings of vegetables and fruit (at least 5 a day) gets you going in the right direction.

So, you think you want the benefits of broccoli but don't care for it? Broccoli is a member of the Brassica group of vegetables in the mustard family. Here are "close relatives" of broccoli that you might want to include in your 5-(or more)-a-day:

  • Root vegetables — rutabaga, turnips, kohlrabi
  • Leafy vegetables — cabbage, Brussels sprouts, kale, rapini, collard greens, bok choy, napa (Chinese cabbage), mustard greens
  • Flowers — cauliflower, broccoli, broccoflower
  • Seeds — mustard seed and rapeseed (from which canola oil is derived)

1 comment:

Anonymous said...

Thanks for the great post! I forwarded this one to the borderline diabetic half of the family tree. :)