Monday, July 2, 2007

Researchers Identify Alcoholism Subtypes

Analyses of a national sample of individuals with alcohol dependence (alcoholism) reveal five distinct subtypes of the disease, according to a new study by scientists at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH).

"Our findings should help dispel the popular notion of the ‘typical alcoholic,’” notes first author Howard B. Moss, M.D., NIAAA Associate Director for Clinical and Translational Research. “We find that young adults comprise the largest group of alcoholics in this country, and nearly 20 percent of alcoholics are highly functional and well-educated with good incomes. More than half of the alcoholics in the United States have no multigenerational family history of the disease, suggesting that their form of alcoholism was unlikely to have genetic causes.”

“Clinicians have long recognized diverse manifestations of alcoholism,” adds NIAAA Director Ting-Kai Li, M.D, “and researchers have tried to understand why some alcoholics improve with specific medications and psychotherapies while others do not.

The researchers identified unique subtypes of alcoholism based on respondents’ family history of alcoholism, age of onset of regular drinking and alcohol problems, symptom patterns of alcohol dependence and abuse, and the presence of additional substance abuse and mental disorders:

Young Adult subtype: 31.5 percent of U.S. alcoholics. Young adult drinkers, with relatively low rates of co-occurring substance abuse and other mental disorders, a low rate of family alcoholism, and who rarely seek any kind of help for their drinking.

Young Antisocial subtype: 21 percent of U.S. alcoholics. Tend to be in their mid-twenties, had early onset of regular drinking, and alcohol problems. More than half come from families with alcoholism, and about half have a psychiatric diagnosis of Antisocial Personality Disorder. Many have major depression, bipolar disorder, and anxiety problems. More than 75 percent smoked cigarettes and marijuana, and many also had cocaine and opiate addictions. More than one-third of these alcoholics seek help for their drinking.

Functional subtype: 19.5 percent of U.S. alcoholics. Typically middle-aged, well-educated, with stable jobs and families. About one-third have a multigenerational family history of alcoholism, about one-quarter had major depressive illness sometime in their lives, and nearly 50 percent were smokers.

Intermediate Familial subtype: 19 percent of U.S. alcoholics. Middle-aged, with about 50 percent from families with multigenerational alcoholism. Almost half have had clinical depression, and 20 percent have had bipolar disorder. Most of these individuals smoked cigarettes, and nearly one in five had problems with cocaine and marijuana use. Only 25 percent ever sought treatment for their problem drinking.

Chronic Severe subtype: 9 percent of U.S. alcoholics. Comprised mostly of middle-aged individuals who had early onset of drinking and alcohol problems, with high rates of Antisocial Personality Disorder and criminality. Almost 80 percent come from families with multigenerational alcoholism. They have the highest rates of other psychiatric disorders including depression, bipolar disorder, and anxiety disorders as well as high rates of smoking, and marijuana, cocaine, and opiate dependence. Two-thirds of these alcoholics seek help for their drinking problems, making them the most prevalent type of alcoholic in treatment.

The authors also report that co-occurring psychiatric and other substance abuse problems are associated with severity of alcoholism and entering into treatment. Attending Alcoholics Anonymous and other 12-step programs is the most common form of help-seeking for drinking problems, but help-seeking remains relatively rare.

Complete article: Researchers Identify Alcoholism Subtypes



Stress + “comfort” foods = excess weight gain

While these scientists have discovered the neurotransmitter and receptor in fat tissue that are activated during stress, (and therefore the chemical receptor blocker); it is great to know that ultimately here is more scientific proof that reducing stress is a powerful method for reducing weight gain, as well as supporting weight loss. It is helpful to note that the rats studied were "stressed," as well as given high-fat foods. The defining outcome is that the stressed, poor-diet fed rats gained more than they would have on the same diet without (or reduced) stress.

Washington, D.C.--In what they call a “stunning research advance,” investigators at Georgetown University Medical Center have been able to use simple, non-toxic chemical injections to add and remove fat in targeted areas on the bodies of laboratory animals. They say the discovery, published online in Nature Medicine on July 1, could revolutionize human cosmetic and reconstructive plastic surgery and treatment of diseases associated with human obesity.

Investigators say these findings may also, over the long-term, lead to better control of metabolic syndrome, which is a collection of risk factors that increase a patient’s chances of developing heart disease, stroke, and diabetes. Sixty million Americans were estimated to be affected by metabolic syndrome in 2000, according to a study funded by the Centers for Disease Control in 2004. In the paper, the Georgetown researchers describe a mechanism they found by which stress activates weight gain in mice, and they say this pathway (which they were able to manipulate) may explain why people who are chronically stressed gain more weight than they should based on the calories they consume.

“An accumulation of chronic stressors, like disagreements with your boss, taking care of a chronically ill child, or repeated traffic road rages, could be acting as an amplifier to a hypercaloric diet when protracted over time. Depression may also be acting as a stressor.” Not only were the stressed mice much fatter, they began to exhibit the metabolic and cardiovascular consequences of obesity, Kuo said. “They had the glucose intolerance seen in diabetes, elevated blood pressure, inflammation in the blood vessels, and fat in their livers and muscles.”

“We are hopeful that these findings might eventually lead to control of metabolic syndrome, which is a huge health issue for many Americans,” she said. “Decreasing fat in the abdomen of the mice we studied reduced the fat in their liver and skeletal muscles, and also helped to control insulin resistance, glucose intolerance, blood pressure and inflammation.
Complete article is posted here:
Scientists Discover Key to Manipulating Fat - Pathway also explains stress-induced weight gain

Wednesday, June 20, 2007

Treat people as if they were what they ought to be...

HeartMath is a registered trademark of the Institute of HeartMath.
HeartQuotes is a trademark of Quantum Intech, Inc.
Copyright © 2007, HeartMath LLC All rights reserved.

Saturday, June 16, 2007

The school of life offers some difficult courses,
but it is in the difficult class that one learns the most.

~ Corrie ten Boom

My Dog is Cool Campaign

Through this website, you'll learn about what you can do to protect dogs from the dangers of hot cars. You can find out how quickly cars heat up in warm weather, whether it's too hot to take your dog along today, and how to get the word out that it's just not cool to leave a dog in a hot car, even for "just a minute."
http://www.mydogiscool.com/

People from a planet without flowers would think we must be mad with joy the whole time to have the things about us.

~ Iris Murdoch




Photo 2006, Janis Davies. All Rights Reserved.

Friday, June 8, 2007

Gratitude...

"Gratitude is the fairest blossom which springs from the soul." -
Henry Ward Beecher

Character...

HeartMath is a registered trademark of the Institute of HeartMath.
HeartQuotes is a trademark of Quantum Intech, Inc. Copyright © 2007, HeartMath LLC All rights reserved.